A non‐canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM 1 phosphorylation
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چکیده
منابع مشابه
A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation.
Centrioles are the major constituents of the animal centrosome, in which Plk4 kinase serves as a master regulator of the duplication cycle. Many eukaryotes also contain numerous peripheral particles known as centriolar satellites. While centriolar satellites aid centriole assembly and primary cilium formation, it is unknown whether Plk4 plays any regulatory roles in centriolar satellite integri...
متن کاملScientific Report A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation
Centrioles are the major constituents of the animal centrosome, in which Plk4 kinase serves as a master regulator of the duplication cycle. Many eukaryotes also contain numerous peripheral particles known as centriolar satellites. While centriolar satellites aid centriole assembly and primary cilium formation, it is unknown whether Plk4 plays any regulatory roles in centriolar satellite integri...
متن کاملFOP Is a Centriolar Satellite Protein Involved in Ciliogenesis
Centriolar satellites are proteinaceous granules that are often clustered around the centrosome. Although centriolar satellites have been implicated in protein trafficking in relation to the centrosome and cilium, the details of their function and composition remain unknown. FOP (FGFR1 Oncogene Partner) is a known centrosome protein with homology to the centriolar satellite proteins FOR20 and O...
متن کاملWDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis.
Ciliogenesis initiates at the mother centriole through a series of events that include membrane docking, displacement of cilia-inhibitory proteins and axoneme elongation. Centriolar proteins, in particular at distal and subdistal appendages, carry out these functions. Recently, cytoplasmic complexes named centriolar satellites have also been shown to promote ciliogenesis. Little is known about ...
متن کاملWDR8 is a centriolar satellite and centriole-associate protein that promotes ciliary vesicle docking during ciliogenesis
Ciliogenesis initiates at the mother centriole through a series of events that include membrane-docking, displacement of cilia-inhibitory proteins and axoneme elongation. Centriolar proteins, in particular at distal and subdistal appendages, carry out these functions. Recently, cytoplasmic complexes named centriolar satellites were also shown to promote ciliogenesis. Little is known about the f...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2016
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201541432